Upturn Strategies for Arachidonic Acid-Induced MC3T3-E1—625 nm Irradiation in Combination with NSAIDs: Dissipating Inflammation and Promoting Healing

نویسندگان

چکیده

Oral surgery, such as tooth extractions and dental implantations, can cause inflammation in the surrounding tissue, especially bones. Anti-inflammatory drugs are crucial for pain relief wound healing. Nonsteroidal anti-inflammatory (NSAIDs) light-emitting diode irradiation (LEDI) at 625 nm have been used therapies to reduce inflammation, which ultimately promotes The mechanism of these two methods, however, is different, possibly makes combined use approaches effective. Therefore, efficacy LEDI, NSAIDs, or a combination both on healing effects were analyzed MC3T3-E1. In this study, piroxicam, ibuprofen, indomethacin, celecoxib selected NSAIDs. effect LEDI was investigated by cell viability, prostaglandin E2 (PGE2) release, expression inflammation-related proteins migration-related evaluated. Additionally, alkaline phosphatase staining with activity, migration assay BrdU proliferation assays performed. Both NSAIDs reduced cyclooxygenase-2 (COX-2) PGE2. promoted migration, proliferation, bone formation well, but not Thus, benefits cells provides upturn strategies after extraction.

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ژورنال

عنوان ژورنال: Photonics

سال: 2023

ISSN: ['2304-6732']

DOI: https://doi.org/10.3390/photonics10050535